Mpox vaccination toolkit

Miluka Gunaratna

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This toolkit offers a set of practical guidance, training, and information resources to support relevant stakeholders to prepare, plan, implement, and monitor mpox vaccination in African countries.

Policy: documents to support NITAGs

TitleAuthorYearTypeLanguage
Smallpox and mpox (orthopoxviruses): WHO position paperWorld Health Organization (WHO)2024GuidanceEnglish, French
Summary of WHO SAGE recommendations for mpox vaccines, including considerations for off-label useWorld Health Organization (WHO)2025PresentationEnglish
Off-label vaccine use: explanatory note for countriesWorld Health Organization (WHO)2024GuidanceEnglish
MVA-BN (‎Modified Vaccinia Ankara – Bavarian Nordic)‎ smallpox and mpox vaccine: Interim guidanceWorld Health Organization (WHO)2024GuidanceEnglish, French
ETF statement on the use of Imvanex for the prevention of mpox in children below 12 years of ageEuropean Medicines Agency2024GuidanceEnglish
Regulatory & Policy Considerations for Mpox Vaccines in African CountriesWorld Health Organization (WHO), European Medicines Agency, Bavarian Nordic2025PresentationEnglish
LC16m8 (live-attenuated freeze-dried vaccinia) smallpox and mpox vaccine - Interim GuidanceWorld Health Organization (WHO)2025GuidanceEnglish, French
Frequently Asked Questions (FAQ) on use of fractional dosing with intradermal administration of mpox MVA-BN vaccine in the context of vaccine supply-constrained outbreak responseWorld Health Organization (WHO)2025GuidanceEnglish

Planning: templates and tools to support development of national mpox national preparedness and deployment plans

TitleAuthorYearTypeLanguage
Request for support for Mpox vaccination response - TemplateWorld Health Organization (WHO), Africa CDC2024ToolEnglish, French
Mpox vaccine doses estimates (Annexe 1)World Health Organization (WHO)2024ToolEnglish, French
Mpox Vaccine deployment plan - Budget template (Annexe 2)World Health Organization (WHO)2024ToolEnglish, French
Mpox vaccine request guidanceWorld Health Organization (WHO)2024GuidanceEnglish, French
Accessing mpox vaccines through the Access and Allocation Mechanism (AAM)WHO Regional Office for Africa (AFRO)2025GuidanceEnglish

Training on mpox vaccination

TitleAuthorYearTypeLanguage
Sample Mpox Training Objectives and AgendaWorld Health Organization (WHO)2024TrainingEnglish
Module 2: Mpox vaccines and vaccination strategies for outbreak responseWorld Health Organization (WHO)2025TrainingEnglish
Module 3: Mva-bn vaccine overviewWorld Health Organization (WHO)2024TrainingEnglish
Module 1: Overview of mpox disease, diagnosis & self-protectionWorld Health Organization (WHO)2024TrainingEnglish
Module 4 : Monitoring mpox vaccination WHO Regional Office for Africa (AFRO)2025TrainingEnglish
Module B: LC16m8 VACCINE administration & Counselling information for vaccine recipients and caregiversWorld Health Organization (WHO)2025TrainingEnglish, French
Module A: LC16m8 VACCINE CHARACTERISTICS and cold chain managementWorld Health Organization (WHO)2025TrainingEnglish, French

Other relevant material

TitleAuthorYearTypeLanguage
How to achieve and sustain high uptake of mpox vaccination in outbreak settingsWorld Health Organization (WHO), UNICEF, International Federation of Red Cross and Red Crescent Societies (IFRC)2025GuidanceEnglish
Strengthening Risk Communication and Community Engagement (RCCE) to Drive Greater Demand and Acceptance of the Mpox VaccineWHO Regional Office for Africa (AFRO), Africa CDC2025TrainingEnglish