This page provides a list of core reference material published by the WHO Expanded Programme on Immunization (EPI) and has been organised into the following three sections. These documents, as well as additional immunization materials, can be found in the Immunization, Vaccines and Biologicals (IVB) Document Centre.
- Adverse Events Following Immunization (AEFI) Surveillance
- Controlled temperature chain (CTC) and Extended Controlled Temperature Conditions (ECTC)
- Health Systems Strengthening (HSS)
- Immunization Agenda 2030
- Immunological Basis for Immunization
- Integration
- Market Information for Access (MI4A)
- Missed opportunities for vaccination (MOV)
- Monitoring, data and coverage
- Planning and financing
- Private sector
- Routine immunization and vaccine introduction
- School-based & life-course vaccination
- Second Year of Life (2YL)
- Supply chain and logistics
- Training and e-Learning
- Vaccine Safety
- Vaccination & Surveillance in Humanitarian Emergencies
- Vaccine-preventable disease (VPD) surveillance
- WHO: general
By antigen
BCG
| Titre | Auteur | Année | Type | Langue |
|---|---|---|---|---|
| BCG vaccines: WHO position paper | World Health Organization (WHO) | Guidance | Arabe, Chinois, Anglais, Français, Russe, Espagnol |
Cholera
| Titre | Auteur | Année | Type | Langue |
|---|---|---|---|---|
| Cholera vaccines: WHO position paper | World Health Organization (WHO) | 2017 | Guidance | Anglais, Français |
| Ending Cholera: A Global Roadmap to 2030 | Global Task Force on Cholera Control | 2017 | Guidance | Anglais |
COVID-19
Please refer to the Covid-19 - Technical resources page.
Dengue
| Titre | Auteur | Année | Type | Langue |
|---|---|---|---|---|
| Informing vaccination programs: a guide to the design and conduct of dengue serosurveys | World Health Organization (WHO) | 2017 | Guidance | Anglais |
| Note de synthèse: position de l’OMS sur les vaccins contre la dengue – mai 2024 | World Health Organization (WHO) | 2024 | Journal article | Français |
| WHO position paper on dengue vaccines – May 2024 | World Health Organization (WHO) | 2024 | Journal article | Anglais |
Diphteria
| Titre | Auteur | Année | Type | Langue |
|---|---|---|---|---|
| Diphtheria vaccine: WHO position paper | World Health Organization (WHO) | Guidance | Arabe, Chinois, Anglais, Français, Russe, Espagnol |
Hepatitis B
| Titre | Auteur | Année | Type | Langue |
|---|---|---|---|---|
| A guide for introducing and strengthening Hepatitis B birth dose vaccination | Morgan et al. | 2015 | Guidance | Arabe, Anglais, Français, Espagnol |
| Documenting the impact of hepatitis B immunization: Best practices for conducting a serosurvey | World Health Organization (WHO) | 2011 | Guidance | Anglais, Français |
| Hepatitis B vaccines: WHO position paper - July 2017 | World Health Organization (WHO) | 2017 | Guidance | Arabe, Chinois, Anglais, Français, Russe, Espagnol |
| Practices to improve coverage of the hepatitis B birth dose vaccine | World Health Organization (WHO) | 2013 | Guidance | Arabe, Anglais, Français |
| Sample design and procedures for Hepatitis B immunization surveys: A companion to the WHO cluster survey reference manual | World Health Organization (WHO) | 2012 | Guidance | Anglais |
Hib
| Titre | Auteur | Année | Type | Langue |
|---|---|---|---|---|
| Haemophilus influenzae type b (Hib) Vaccination: WHO position paper | World Health Organization (WHO) | Guidance | Arabe, Chinois, Anglais, Français, Russe, Espagnol | |
| Measuring impact of Streptococcus pneumoniae and Haemophilus influnzae type b conjugate vaccination | World Health Organization (WHO) | 2012 | Guidance | Anglais |
HPV
| Titre | Auteur | Année | Type | Langue |
|---|---|---|---|---|
| Guide to introducing HPV vaccine into national immunization programmes | World Health Organization (WHO) | 2016 | Guidance | Portuguais |
| HPV Vaccine Communication: Special considerations for a unique vaccine | Christine McNab, Tracey Goodman, Susan Wang | Guidance | Anglais | |
| HPV Vaccine Introduction Clearing House | World Health Organization (WHO) | 1960 | Repository | Anglais |
| Human papillomavirus vaccines: WHO position paper, December 2022 | World Health Organization (WHO) | Guidance | Arabe, Chinois, Anglais, Français, Russe, Espagnol | |
| Lier les interventions sanitaires à l’intention des adolescents avec la vaccination anti-PVH : différentes options | World Health Organization (WHO) | 2014 | Guidance | Anglais, Français, Russe, Espagnol |
| Options for linking health interventions for adolescents with HPV vaccination | World Health Organization (WHO) | 2014 | Guidance | Anglais, Français, Russe, Espagnol |
| PRIME cost effectiveness tool | World Health Organization (WHO) | Tool | Anglais | |
| Scaling-up HPV vaccine introduction | World Health Organization (WHO) | 2016 | Guidance | Anglais, Français |
| WHO Cervical Cancer Prevention and Control Costing Tool (C4P) | World Health Organization (WHO) | Tool | Anglais, Français |
Influenza
| Titre | Auteur | Année | Type | Langue |
|---|---|---|---|---|
| How to implement seasonal influenza vaccination of health workers: an introduction manual for national immunization programme managers and policy makers | World Health Organization (WHO) | 2019 | Guidance | Arabe, Chinois, Anglais, Français, Russe, Espagnol |
| Influenza economics assessments | World Health Organization (WHO) | 2016 | Repository | Arabe, Chinois, Anglais, Français, Russe, Espagnol |
| Influenza immunization: Guidance to inform introduction of influenza vaccine in low and middle-income countries | World Health Organization (WHO) | 2017 | Guidance | Anglais, Russe |
| Influenza Vaccine Post-Introduction Evaluation (IPIE) | World Health Organization (WHO) | 2018 | Guidance | Anglais |
Japanese encephalitis (JE)
| Titre | Auteur | Année | Type | Langue |
|---|---|---|---|---|
| Japanese Encephalitis Vaccines: WHO position paper | World Health Organization (WHO) | Guidance | Arabe, Chinois, Anglais, Russe, Espagnol | |
| Note de synthèse: position de l’OMS à propos des vaccins contre l’encéphalite japonaise – février 2015 | World Health Organization (WHO) | 2015 | Journal article | Français |
Malaria vaccine
| Titre | Auteur | Année | Type | Langue |
|---|---|---|---|---|
| First malaria vaccine in Africa: A potential new tool for child health and improved malaria control | World Health Organization (WHO) | 2019 | Guidance | Anglais |
| Malaria vaccine: WHO position paper – May 2024 | World Health Organization (WHO) | 2024 | Journal article | Anglais |
| Q&A on the malaria vaccine implementation programme (MVIP) | World Health Organization (WHO) | 2019 | Guidance | Anglais |
| Q&A on the Phase 3 trial results for malaria vaccine RTS,S/AS01 | World Health Organization (WHO) | 2017 | Repository | Anglais |
Measles and rubella
Meningitis
Mumps
| Titre | Auteur | Année | Type | Langue |
|---|---|---|---|---|
| Mumps vaccines: WHO position paper | World Health Organization (WHO) | 2024 | Guidance | Anglais |
| Note de synthèse: position de l’OMS sur les vaccins antiourliens - mars 2024 | World Health Organization (WHO) | 2024 | Journal article | Français |
Pertussis
| Titre | Auteur | Année | Type | Langue |
|---|---|---|---|---|
| Generic protocol for estimating the burden of Pertussis in young children | World Health Organization (WHO) | 2005 | Guidance | Anglais |
| Laboratory Manual for the diagnosis of whooping cough caused by bordetella pertussis/bordetella parapertussis : update 2014 | World Health Organization (WHO) | 2014 | Guidance | Anglais |
| Pertussis vaccines: WHO position paper | World Health Organization (WHO) | Guidance | Arabe, Chinois, Anglais, Français, Russe, Espagnol |
Pneumococcal
| Titre | Auteur | Année | Type | Langue |
|---|---|---|---|---|
| Characteristics of different presentations of Pneumococcal Conjugate Vaccines | World Health Organization (WHO) | 2017 | Poster/infographic | Anglais |
| Pneumococcal Conjugate Vaccine (PCV) 4-dose vial presentations - Frequently Asked Questions (FAQs) | Gavi, the Vaccine Alliance | 2017 | Guidance | Anglais |
| Pneumococcal Vaccine: Handling the change in product manufacturer and presentation | World Health Organization (WHO) | 2017 | Guidance | Portuguais |
Polio
Rabies
| Titre | Auteur | Année | Type | Langue |
|---|---|---|---|---|
| Rabies vaccines: WHO position paper | World Health Organization (WHO) | Guidance | Arabe, Chinois, Anglais, Français, Russe, Espagnol | |
| WHO Expert Consultation on Rabies, 2nd report | World Health Organization (WHO) | 2013 | Report | Anglais |
Rotavirus
| Titre | Auteur | Année | Type | Langue |
|---|---|---|---|---|
| Generic protocol for monitoring impact of rotavirus vaccination on gastroenteritis disease burden and viral strains | World Health Organization (WHO) | 2009 | Guidance | Anglais |
| Manual of rotavirus detection and characterization methods | World Health Organization (WHO) | 2009 | Guidance | Anglais |
| Post-marketing surveillance of rotavirus vaccine safety | World Health Organization (WHO) | 2009 | Guidance | Anglais |
| Rotavirus vaccines: WHO position paper | World Health Organization (WHO) | Guidance | Arabe, Chinois, Anglais, Français, Russe, Espagnol |
Tetanus
| Titre | Auteur | Année | Type | Langue |
|---|---|---|---|---|
| Protecting All Against Tetanus: Guide to sustaining maternal and neonatal tetanus elimination (MNTE) and broadening tetanus protection for all populations | World Health Organization (WHO) | 2019 | Guidance | Anglais |
| Replacement of TT with Td vaccine – July 2018 | UNICEF, World Health Organization (WHO) | 2018 | Guidance | Français |
| Use of tetanus-diphtheria (Td) vaccine in children 4–7 years of age: World Health Organization consultation of experts | Heather M. Scobie, S. Desai, Thomas Cherian, Tracey Goodman | 2020 | Journal article | Anglais |
| Validation of Maternal and Neonatal Tetanus Elimination | World Health Organization (WHO) | 2014 | Guidance | Anglais, Français |
Typhoid
| Titre | Auteur | Année | Type | Langue |
|---|---|---|---|---|
| Typhoid vaccines: WHO position paper – March 2018 | World Health Organization (WHO) | 2018 | Guidance | Anglais, Français |
Varicella/ Herpes Zoster
| Titre | Auteur | Année | Type | Langue |
|---|---|---|---|---|
| Varicella and herpes zoster vaccines: WHO position paper, June 2014 - Recommendations. | World Health Organization (WHO) | Guidance | Anglais |
Yellow fever
| Titre | Auteur | Année | Type | Langue |
|---|---|---|---|---|
| Eliminate Yellow fever Epidemics (EYE): a global strategy, 2017–2026 | Justus Benzler, Laurence Cibrelus Yamamoto, Sergio Yactayo | 2017 | Journal article | Anglais |
| Global Strategy to Eliminate Yellow Fever Epidemics (EYE) | World Health Organization (WHO) | 2016 | Guidance | Anglais |
| Yellow fever vaccine: WHO position on the use of fractional doses – June 2017 | World Health Organization (WHO) | 2017 | Journal article | Anglais, Français |
| Yellow Fever vaccines: WHO position paper | World Health Organization (WHO) | Guidance | Arabe, Chinois, Anglais, Français, Russe, Espagnol |
By theme
Adverse Events Following Immunization (AEFI) Surveillance
| Titre | Auteur | Année | Type | Langue |
|---|---|---|---|---|
| Global Manual on Surveillance of Adverse Events Following Immunization | World Health Organization (WHO) | Guidance | Anglais |
Controlled Temperature Chain (CTC) and Extended Controlled Temperature Conditions (ECTC)
Note: for additional information on CTC and ECTC, please refer to Controlled temperature chain - technical resources.
| Titre | Auteur | Année | Type | Langue |
|---|---|---|---|---|
| Background material and other CTC resources | World Health Organization (WHO) | Repository | Français | |
| Controlled temperature chain: Strategic Roadmap for Priority Vaccines 2017-2020 | World Health Organization (WHO) | 2018 | Guidance | Anglais |
| Countries’ interest in a hepatitis B vaccine licensed for the controlled temperature chain; survey results from African and Western Pacific regions | Dörte Petit, Carole Tevi-Benissan, Joseph Woodring, Karen Hennessey, Anna-Lea Kahn | 2017 | Journal article | Anglais |
| ECTC infographic | World Health Organization (WHO) | Poster/infographic | Anglais | |
| The controlled temperature chain (CTC): frequently asked questions | World Health Organization (WHO) | 2016 | Guidance | Anglais |
| What is a controlled temperature chain? (CTC) - Infographic | World Health Organization (WHO) | 2015 | Poster/infographic | Anglais |
Health Systems Strengthening (HSS)
| Titre | Auteur | Année | Type | Langue |
|---|---|---|---|---|
| A system-wide approach to analysing efficiency across health programmes | World Health Organization (WHO) | 2017 | Guidance | Anglais, Français |
| Aligning public financial management and health financing | World Health Organization (WHO) | 2017 | Guidance | Anglais |
| Developing a national health financing strategy: a reference guide | World Health Organization (WHO) | 2017 | Guidance | Anglais |
| Towards UHC: thinking public - Overview of trends in public expenditure on health (2000-2014) | World Health Organization (WHO) | 2017 | Report | Anglais |
Immunological Basis for Immunization
| Titre | Auteur | Année | Type | Langue |
|---|---|---|---|---|
| The Immunological Basis for Immunization Series | World Health Organization (WHO) | Repository | Anglais |
Immunization Agenda 2030
| Titre | Auteur | Année | Type | Langue |
|---|---|---|---|---|
| Immunization Agenda 2030: A Global Strategy to Leave No One Behind | IA2030 Partnership | Guidance | Arabe, Chinois, Anglais, Français, Russe, Espagnol |
Integration
Market Information for Access (MI4A)
Missed opportunities for vaccination (MOV)
| Titre | Auteur | Année | Type | Langue |
|---|---|---|---|---|
| Intervention guidebook for implementing and monitoring activities to reduce Missed Opportunities for Vaccination | World Health Organization (WHO) | 2019 | Guidance | Anglais, Français |
| Methodology for the Assessment of Missed Opportunities for Vaccination | World Health Organization (WHO) | 2017 | Guidance | Anglais |
| Planning Guide to Reduce Missed Opportunities for Vaccination | World Health Organization (WHO) | 2017 | Guidance | Anglais, Français, Portuguais |
Monitoring, data and coverage
Note: for additional resources on home-based records (HBRs), please refer to Home-based records.
Planning and financing
| Titre | Auteur | Année | Type | Langue |
|---|---|---|---|---|
| Immunization Financing A resource guide for advocates, policymakers, and program managers | Results for Development (R4D) | Guidance | Anglais | |
| Immunization financing guidance and tools | World Health Organization (WHO) | Repository | Anglais |
Private sector
| Titre | Auteur | Année | Type | Langue |
|---|---|---|---|---|
| WHO Guidance Note: Engagement of private providers in immunization service delivery. Considerations for National Immunization Programmes | World Health Organization (WHO) | 2017 | Guidance | Anglais |
Routine immunization and vaccine introduction
School-based & life-course vaccination
| Titre | Auteur | Année | Type | Langue |
|---|---|---|---|---|
| Checking vaccination status at entry to, or during school | World Health Organization (WHO) | 2019 | Guidance | Anglais |
| Considerations regarding consent in vaccinating children and adolescents between 6 and 17 years old | World Health Organization (WHO) | 2014 | Guidance | Anglais |
| Global Accelerated Action for the Health of Adolescents (AA-HA!): guidance to support country implementation | World Health Organization (WHO) | 2017 | Guidance | Anglais |
| Global Strategy for Women's, Children's and Adolescents Health 2016-2030 | World Health Organization (WHO) | 2015 | Guidance | Espagnol |
| School Vaccination Readiness Assessment Tool | World Health Organization (WHO) | 2013 | Guidance | Anglais |
Second Year of Life (2YL)
| Titre | Auteur | Année | Type | Langue |
|---|---|---|---|---|
| A practical handbook for planning, implementing, and strengthening vaccination in the second year of life | World Health Organization (WHO) | 2019 | Guidance | Anglais, Français, Portuguais |
| Establishing and strengthening immunization in the second year of life (2YL) - resource page | World Health Organization (WHO) | Repository | Anglais, Français | |
| Establishing and strengthening immunization in the second year of life: Practices for immunization beyond infancy | World Health Organization (WHO) | Guidance | Anglais, Français, Portuguais |
Supply chain and logistics
In addition to the list given below, the following pages also provide technical resources:
- Cold chain equipment management - technical resources
- Effective Vaccine Management - technical resources
- Immunization supply chain planning tools
| Titre | Auteur | Année | Type | Langue |
|---|---|---|---|---|
| Achieving immunization targets with the comprehensive effective vaccine management (EVM) framework | UNICEF, World Health Organization (WHO) | 2016 | Guidance | Anglais |
| Cold room temperature mapping studies | World Health Organization (WHO) | 2018 | Guidance | Anglais |
| EVM assessment tools and user guides | World Health Organization (WHO) | 2019 | Repository | Anglais |
| EVM Global Data Analysis | World Health Organization (WHO) | 2018 | Guidance | Anglais |
| EVM Standard Operating Procedures (SOPs) | World Health Organization (WHO) | 2013 | Guidance | Anglais, Français |
| How to Develop a Continuous Improvement Plan (cIP) | UNICEF, World Health Organization (WHO) | 2018 | Guidance | Arabe, Anglais |
| Immunization supply chain and logistics - A neglected but essential system for national immunization programmes | World Health Organization (WHO) | 2014 | Guidance | Anglais, Français |
| Off-label use of vaccines | Pieter Neels, James Southern, Jon Abramson, Philippe Duclos, Joachim Hombach, Melanie Marti, Alanna Fitzgerald-Husek, Jacqueline Fournier-Caruana, Germaine Hanquet | 2017 | Journal article | Anglais |
| Perception of health workers on the use of 30-day temperature recorders | World Health Organization (WHO) | 2018 | Guidance | Anglais |
| Perception of health workers on the use of remote temperature monitoring systems | World Health Organization (WHO) | 2018 | Guidance | Anglais |
| Solar direct-drive vaccine refrigerators and freezers | 2017 | Guidance | Anglais | |
| System design approach to improve the immunization supply chain | World Health Organization (WHO) | 2018 | Guidance | Anglais |
| Temperature monitoring study: a fully documented process to detect weaknesses in the supply chain | World Health Organization (WHO) | 2018 | Guidance | Anglais |
| Vaccine Management Handbook | UNICEF, World Health Organization (WHO) | 2015 | Guidance | Français |
| WHO guidance note: Vaccine diluents, revision 2015 | World Health Organization (WHO) | 2015 | Guidance | Anglais |
| WHO policy on the use of opened multi-dose vaccine vials (2014 Revision) | World Health Organization (WHO) | 2014 | Guidance | Français |
Training and e-Learning
| Titre | Auteur | Année | Type | Langue |
|---|---|---|---|---|
| Agora - E-learning modules on immunization | UNICEF | 2020 | Training | Anglais |
| E-learning course on Vaccine Safety Basics | World Health Organization (WHO) | 2013 | Training | Français |
| Effective Vaccine Management (EVM) training resources | World Health Organization (WHO) | Repository | Français | |
| Immunization in Practice: a practical guide for health staff, 2015 update | World Health Organization (WHO) | 2015 | Guidance | Français |
| Immunization training resources | World Health Organization (WHO) | 2020 | Training | Anglais |
| Vaccination in humanitarian emergencies | World Health Organization (WHO) | Repository | Anglais |
Vaccination & Surveillance in Humanitarian Emergencies
| Titre | Auteur | Année | Type | Langue |
|---|---|---|---|---|
| Outbreak surveillance and response in humanitarian emergencies: WHO guidelines for EWARN implementation | World Health Organization (WHO) | Guidance | Anglais | |
| Vaccination in acute humanitarian emergencies: a framework for decision making | World Health Organization (WHO) | 2017 | Guidance | Anglais, Français, Russe |
| Vaccination in humanitarian emergencies – eTool and eLearning course | World Health Organization (WHO) | Repository | Anglais | |
| Vaccination in Humanitarian Emergencies: Implementation Guide | World Health Organization (WHO) | 2017 | Guidance | Français |
Vaccine Safety
| Titre | Auteur | Année | Type | Langue |
|---|---|---|---|---|
| E-learning course on Vaccine Safety Basics | World Health Organization (WHO) | 2013 | Training | Français |
| The Global Advisory Committee on Vaccine Safety | World Health Organization (WHO) | 1960 | Repository | Anglais |
| The Global Vaccine Safety Initiative (GVSI) | World Health Organization (WHO) | Repository | Français |
Vaccine-preventable Disease (VPD) Surveillance
| Titre | Auteur | Année | Type | Langue |
|---|---|---|---|---|
| Global framework for immunization monitoring and surveillance | Centers for Disease Control and Prevention (CDC), World Health Organization (WHO) | 2007 | Guidance | Anglais |
| Global Strategy on Comprehensive Vaccine-Preventable Disease Surveillance | World Health Organization (WHO) | 2020 | Guidance | Anglais |
| Overview: Vaccine Preventable Diseases Surveillance Standards | World Health Organization (WHO) | 2017 | Guidance | Anglais, Russe |
| WHO manual for organizing a national external quality assessment programme for health laboratories and other testing sites | World Health Organization (WHO) | 2016 | Guidance | Anglais |
WHO: general
| Titre | Auteur | Année | Type | Langue |
|---|---|---|---|---|
| Thirteenth general programme of work 2019−2023 | World Health Assembly | 2018 | Guidance | Espagnol |
| WHO Accountability Framework | World Health Organization (WHO) | 2015 | Guidance | Anglais |
| WHO: The Global Guardian of Public Health | World Health Organization (WHO) | 1960 | Guidance | Espagnol |
| WHO’s Mission and Vision in Immunization and Vaccines (2015-2030) | World Health Organization (WHO) | 2016 | Guidance | Anglais |
By group
Immunization Practices Advisory Committee (IPAC)
| Titre | Auteur | Année | Type | Langue |
|---|---|---|---|---|
| Immunization Practices Advisory Committee (IPAC) | World Health Organization (WHO) | Repository | Anglais | |
| Immunization Practices Advisory Committee (IPAC) meeting reports | World Health Organization (WHO) | Repository | Anglais |
Immunization and vaccines related implementation research advisory committee (IVIR-AC)
| Titre | Auteur | Année | Type | Langue |
|---|---|---|---|---|
| Immunization and vaccines related implementation research advisory committee (IVIR-AC) | World Health Organization (WHO) | Repository | Anglais | |
| IVIR-AC Meeting reports and executive summaries | World Health Organization (WHO) | Repository | Anglais |
National Immunization Technical Advisory Groups (NITAGs)
Strategic Advisory Group of Experts [on immunization]
| Titre | Auteur | Année | Type | Langue |
|---|---|---|---|---|
| SAGE Meeting Reports | World Health Organization (WHO) | Repository | Anglais |