Post00358 VVM NEWS 19 July 2001
CONTENTS
1. GOOD NEWS - VVM IMPLEMENTATION: BCG & MEASLES
*Umit Kartoglu, WHO/V&B/ATT, posts the good news that more vaccine with
Vaccine Vial Monitors will be supplied to countries this year.
* This should lead us to the 'Cold Chain of the Future' soon!
* How will it work? * How will we make it happen?
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From: [log in to unmask]
To: [log in to unmask]
Subject: Good news - VVM implementation
Date: Tue, 17 Jul 2001
Dear Allan,
I have good news on VVM implementation to share with Technet members.
First one is from Japan BCG. We have been informed that Japan BCG will start
supplying BCG with VVM attached to UNICEF in August. A total of 1.5 million
ampoules of 20 doses BCG will be delivered to countries.
Second one is from Japan International Corporation System (JICS) about a
decision that all vaccines donated by JICS will have VVMs attached. Measles
vaccine will be the first one to be donated with VVMs.
VVMs on freeze dried vaccines are attached either on the cap or on the neck
of the ampoule. Health workers will refer to VVM until the time of
reconstitution. During reconstitution VVM is removed (with the cap or with
the neck of the ampoule) and should not be referred to any more.
Reconstituted BCG and measles vaccines must be discarded within 6 hours or
at the end of the session whichever comes first.
VVM on freeze dried vaccines always comes in DOT form. Since the VVM has to
be attached to a place allowing its removal during reconstitution, it cannot
be attached to the label.
Interpretation of different type VVMs is the same as in OPV VVMs. When the
inner square color matches the circle, the vial must not be used and
discarded. However, it should be noted that even [when] exposed to the same
temperatures, the VVM on OPV vaccine will reach its end point much faster
than BCG and measles VVMs. This is mainly due to difference in vaccine
stability and therefore VVM reaction rate. Japan BCG will have VVM30 which
reaches its discard point at 37degree C in 30 days, and Measles will have VVM7
showing the same reaction at the same temperature in 7 days. OPV VVM is VVM2
and reaction time to reach its discard point is 2 days at 37degree C. This is
again to underline that the VVM is a smart indicator of heat exposure for
the individual vial/ampoule to which it is affixed.
Warm regards,
Umit Kartoglu
Dr. Umit Kartoglu
Technical Officer
V&B/ATT, HTP Room M230
World Health Organization
Avenue Appia 20, CH-1211 Geneva 27
Switzerland
Tel: +41 22 791 4972; Fax: +41 22 791 4384
Mobile: +41 79 475 5467
e-mail: [log in to unmask]
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