The need to keep vaccines in a 2°C to 8°C cold chain is a constraining factor for many immunization campaigns due to limited storage capacity and/or limited ice pack freezing capacity; supplementary immunization activities planned across sub-Saharan Africa are a good example. In 2012, the license for the Serum Institute of India’s meningitis A vaccine, MenAfriVac™, was changed based on a thorough review of scientific data by regulatory authorities and the World Health Organization (WHO) to allow for the use of the vaccine for a period of up to four days at temperatures of up to 40°C in a controlled temperature chain (CTC). This document provides countries with guidance on when and how to take advantage of this flexibility.
Publisher
World Health Organization
Categories
- Vaccines & delivery devices
Organisations
- World Health Organisation (WHO)
Tags
- Controlled temperature chain (CTC)
- MenAfriVac
Topic references
CTC_PUBLICATIONS
Title | Author | Year | Type | Language |
Guidelines on the stability evaluation of vaccines for use under extended controlled temperature conditions, Annex 5, TRS No 999 | World Health Organization (WHO) | 2016 | Guidance | English |
Comment contrôler la température dans la chaîne d'approvisionnement en vaccins | World Health Organization (WHO) | 2015 | Guidance | French |
Controlled temperature chain for vaccination in low- and middle-income countries: a realist evidence synthesis | Christopher P. Seaman, Anna-Lea Kahn, Debra Kristensen, Robert Steinglass, Dijana Spasenoska, Nick Scott, Christopher Morgan | 2022 | Journal article | English |
Delivering MenAfriVac using the controlled temperature chain approach | PATH, World Health Organization (WHO) | 2013 | Case study | English, French |
Hepatitis B vaccines: WHO position paper - July 2017 | World Health Organization (WHO) | 2017 | Guidance | Arabic, Chinese, English, French, Russian, Spanish |
How to monitor temperatures in the vaccine supply chain | UNICEF, World Health Organization (WHO) | 2015 | Guidance | English |
Labelling Guidance for Controlled Temperature Chain (CTC) Qualification for Vaccine Manufacturers (2020) | World Health Organization (WHO) | 2020 | Guidance | English |
Use of MenAfriVac™ (meningitis A vaccine) in a controlled temperature chain (CTC) during campaigns : adaptation guide and facilitators guide | World Health Organization (WHO) | 2013 | Guidance | English |
Use of MenAfriVac™ (meningitis A vaccine) in a controlled temperature chain (CTC) during campaigns : training module for organizing immunization sessions | World Health Organization (WHO) | 2013 | Training | English |
Use of MenAfriVac™ (meningitis A vaccine) in a controlled temperature chain (CTC) during campaigns: guidance for immunization programme decision-makers and managers | World Health Organization (WHO) | 2013 | Guidance | English, French |
Utilisation du MenAfriVac™ (vaccin contre la méningite A) en chaîne à température contrôlée (CTC) pendant les campagnes - Guide à l'intention des décideurs et des administrateurs des programmes de vaccination | World Health Organization (WHO) | 2013 | Guidance | French |
Utilisation du MenAfriVac™ (vaccin contre la méningite A) en chaîne à température contrôlée (CTC) pendant les campagnes - Guide d'adaptation et guide du formateur | World Health Organization (WHO) | 2013 | Guidance | French |
Utilisation du MenAfriVac™ (vaccin contre la méningite A) en chaîne à température contrôlée (CTC) pendant les campagnes - Module de formation pour l'organisation de séances de vaccination | World Health Organization (WHO) | 2013 | Training | French |
EPI-CORE-MENINGITIS
OPTIMIZE_CTC
Added by: Dan Brigden
Added on: 2015-08-13 13:14:26
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