Journal article
Assessing the potency of oral polio vaccine kept outside of the coldchain
This study is the first systematic documentation of the potency of monovalent oral polio vaccine type 3 (mOPV3) kept at ambient temperatures during a polio immunization campaign in Chad. During the study test vials were exposed to temperatures of up to 47.1 °C, and kept outside of the 2–8 °C range for a maximum of 86.9 hours. Post-campaign laboratory testing confirmed that the test vials were still potent, and in conformity with the defined release specifications. Further, the Vaccine Vial Monitors performed as expected, giving an early warning indication of when cumulative exposure to heat reached levels that may have negatively affected the vaccine\'s potency. This study provides proof-of-concept evidence that certain types of OPV remain potent and thus can be kept, for limited periods of time, as well as administered at ambient temperatures.
Authors
Languages
- English
Publication year
2011
Journal
Vaccine
Volume
29
Issue
34
Type
Journal article
Categories
- Supply chain & logistics
Diseases
- Polio
Countries
- Chad
WHO Regions
- African Region
VVM-CTC
You can find more information about "VVM-CTC" in the following Hot Topics:
| Title | Author | Year | Type | Language |
|---|---|---|---|---|
| Vaccines beyond the cold chain - Simona Zipursky | Simona Zipursky, EPELA, World Health Organization (WHO) | 2013 | Guidance | English |
| Benefits of using vaccines out of the cold chain: Delivering Meningitis A vaccine in a controlled temperature chain during the mass immunization campaign in Benin | Simona Zipursky, Mamoudou Harouna Djingarey, Jean-Claude Lodjo, Laifoya Olodo, Sylvestre Tiendrebeogo, Olivier Ronveaux | 2014 | Journal article | English |
| Assessing the potency of oral polio vaccine kept outside of the coldchain | Simona Zipursky, Liliane Boualam, Dah Ould Cheikh, Jacqueline Fournier-Caruana, Djabar Hamid, Mathias Janssen, Umit Kartoglu, Genevieve Waeterloos, Olivier Ronveaux | 2011 | Journal article | English |
| Extending supply chains and improving immunization coverage and equity through controlled temperature chain use of vaccines | Raja Rao, Debra Kristensen, Anna-Lea Kahn | 2017 | Journal article | English |
