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!-- !- e Volume 17, Issue 11 - November 2023 The Measles and Rubella Bulletin is a monthly publication reporting progress towards achieving measles and rubella elimination in the Western Pacific Region. Inside each issue, we present the latest reported data by country on measles and rubella incidence, surveillance performance, ...Post is under moderationStream item published successfully. Item will now be visible on your stream.
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!-- !- e Volume 17, Issue 11 - November 2023 The Measles and Rubella Bulletin is a monthly publication reporting progress towards achieving measles and rubella elimination in the Western Pacific Region. Inside each issue, we present the latest reported data by country on measles and rubella incidence, surveillance performance, ...Post is under moderationStream item published successfully. Item will now be visible on your stream.
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EYE Strategy October newsletter Yellow fever vaccination campaign, Cameroon. May 2022 News release: EYE Strategy mid-term evaluation report Since 2017, according to EYE Strategy data, 248* million more people in Africa have been protected via yellow fever campaigns via a single-dose vaccine that provides...Post is under moderationStream item published successfully. Item will now be visible on your stream.
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Evidence of Extended Thermo-Stability of Typhoid Polysaccharide Conjugate Vaccines
Typhoid conjugate vaccines (TCV) are effective in preventing enteric fever caused by Salmonella enterica serovar Typhi in Southeast Asia and Africa. To facilitate vaccination with the Vi capsular polysaccharide–tetanus toxoid conjugate vaccine, Typbar TCV, and allow it to be transported and stored outside a cold chain just prior to administration, an extended controlled-temperature conditions (ECTC) study was performed to confirm the quality of the vaccine at 40 °C for 3 days at the end of its shelf-life (36 months at 2–8 °C). Studies performed in parallel by the vaccine manufacturer, Bharat Biotech International Limited, and an independent national control laboratory (NIBSC) monitored its stability-indicating parameters: O-acetylation of the Vi polysaccharide, integrity of the polysaccharide–protein conjugate, and its molecular size and pH. ECTC samples stored at 40 °C and 45 °C in comparison with control samples stored at 4 °C and 55 or 56 °C, were shown to have stable O-acetylation and pH; only very slight increases in the percentage of free saccharide and corresponding decreases in molecular size were observed. The deoxycholate method for precipitating conjugated polysaccharide was very sensitive to small incremental increases in percentage of free saccharide, in line with storage temperature and duration. This extended ECTC study demonstrated minimal structural changes to the Vi polysaccharide and conjugate vaccine and a stable formulation following extended exposure to elevated temperatures for the desired durations. This outcome supports the manufacturer’s ECTC claim for the vaccine to be allowed to be taken outside the cold chain before its administration.
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4 minute read NOVEMBER 29, 2023 IN THIS ISSUE The Final #AIRA2024 Abstract Countdown Join AIRA at HIMSS24 in Orlando Information Requests AIRA's New Corporate Partner Product Directory TAKE ACTION The Final #AIRA2024 Abstract Countdown There is now less than one week left to submit your abstracts for consideration for the AIRA ...Post is under moderationStream item published successfully. Item will now be visible on your stream.
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Twenty-fourth meeting of the Global Commission for the Certification of the Eradication of Poliomyelitis (GCC) On 22-23 November 2023, the Global Commission for Certification of Poliomyelitis Eradication (GCC) met in Geneva, Switzerland. Read more in the latest issue of the bulletin Read more in the lat...Post is under moderationStream item published successfully. Item will now be visible on your stream.
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4 minute read NOVEMBER 22, 2023 IN THIS ISSUE Less Than Two Weeks Left to Submit Your Abstract for #AIRA2024 Register Today for AIRA's November Discovery Session Information Requests NEW! AIRA Corporate Partner Product Directory Data Viz Tip of the Month It’s that time of year again when we take a moment to pause, gather, and give tha...Post is under moderationStream item published successfully. Item will now be visible on your stream.
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